The Cellular Senescence Theory Of Aging | Dr Darren Baker Presentation Clips

Dr Darren Baker presents different theories of aging and especially emphasized on the cellular senescence theory of aging in this short clip.

Dr Darren Baker is an Assistant Professor in Mayo Clinic. The research interests of Dr Baker are focused on the involvement of senescent cells in the processes of aging and cancer.

Cellular senescence, a state of irreversible cell cycle arrest that limits the ability of cells to divide, is a potent anti-tumor mechanism that is also a common feature of aged tissue. Instead of simply being resident cells within a tissue, senescent cells promote various age-related phenotypes due to components that they secrete. Studying the role of cellular senescence in vivo, however, has been difficult due to the lack of reliable markers and the inability to selectively manipulate these cells in animals.

Dr. Baker's research team has developed a transgenic mouse model, termed INK-ATTAC, in which p16-expressing senescent cells can be selectively eliminated in an inducible fashion. By using the INK-ATTAC model in combination with an accelerated aging model, Dr. Baker has demonstrated the ability to significantly delay age-related pathologies and phenotypes, including cataract formation, by removing senescent cells.

=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=
https://iherb.co/gTEamWK
iHerb All Supplements & Health Products Discount Link
New Customer 10% off, existed customer 5% off
=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=*=
Please note that the links above are affiliate links, so we receive a small commission when you purchase a product through the links. Thank you for your support!

___________________________________________
DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.

#Senescence #senescentcells #TheoryOfAging #DavidSinclair #Folate #VitaminB12 #MethylDonors #TMG #Epigenetic #sirtuin #NadBooster #Exercise #NAD #BeingHungry #NMN #Rejuvenate #Reprogramming #Mitochondria #ALA #Metformin #PQQ #CoQ10 #Carnitine #Antioxidant #LookYounger #NMN #Resveratrol #Quercetin #Fisetin #senolytics #OliveOil #Sirtuin #HIIT #aging #Lifespan #NMN #NR #Spermidine #Metformin #Berberine #ReverseAging #Epigenetic #OleicAcid #NMN #NAD #Sirtuins #Fasting #Longevity #RestoreYouth #Reprogramming #DavidSinclair #DrSinclairLab #Healthspan #Younger #antiaging #DrSinclair #NAD #longevity #Bioscience #Epigenome