Enantioselective Synthesis of Stereogenic-at-P(V) Building Blocks with Dr. Katherine Forbes

In this Research Spotlight episode, Dr. Katherine Forbes (Jacobsen lab, Harvard) joins us to share her work on the enantioselective synthesis of stereogenic-at-P(V) building blocks.

Key reference:
Science 2022, 376 (6598), 1230–1236.
http://doi.org/10.1126/science.abp8488

Other references (in order of appearance):
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Chem. Rev. 2017, 117 (18), 11753–11795.
[1] ChemInform 2003, 34 (38). [2] Tetrahedron Lett. 1989, 30 (21), 2783–2786. [3] Tetrahedron Lett. 1981, 22 (6), 571–572. [4] J. Am. Chem. Soc. 2013, 135 (7), 2474–2477. [5] J. Am. Chem. Soc. 1993, 115 (23), 11000–11001. [5] J. Am. Chem. Soc. 2020, 142 (12), 5785–5792. [6] J. Org. Chem. 2020. [7] Nat Catal. 2022, 5 (1), 10–19.
J. Am. Chem. Soc. 2020, 142 (12), 5785–5792.
[1] Science 2017, 356 (6336), 426–430. [2] Science 2021, 371 (6530), 702–707.
[1] Bioorg. Med. Chem. 2003, 11 (24), 5461–5484. [2] J. Med. Chem. 2002, 45 (4), 919–929. [3] J. Med. Chem. 2020, 63 (10), 5185–5200. [4] Org. Biomol. Chem. 2015, 13 (18), 5260–5264.