Controlled Microfluidic Production of Core Shell Microparticles for Drug Encapsulation

PLGA is a biocompatible, biodegradable polymer which is widely used in the pharmaceutical industry. PLGA microparticles in particular represent a very successful drug delivery system and can be successfully used to achieve controlled release of both hydrophilic and hydrophobic drugs. Encapsulation of hydrophilic drugs in a polymeric matrix (e.g. PLGA) can be achieved by creating core-shell PLGA microparticles with an aqueous core which contains the hydrophilic drug.

Monodispersity of these PLGA microspheres is essential to target the desired release profile and to enhance the bioavailability of the encapsulated drug. This can be difficult to achieve using traditional batch technology especially when targeting complex micro-particle structures such as core-shell. Microfluidic technology represents an effective way to manufacture micro-particles with complex structures while maintaining a narrow particle size distribution and ensuring a high drug encapsulation efficiency.

This webinar hosted by Dr. Valentina Nappo highlights our latest work on PLGA core-shell microparticles for hydrophilic drug release using Dolomite PLGA Microparticles Synthesis System.

1) Introduction: 0:00 - 2:50
2) Why do we use microfluidics?: 2:50 - 3:40
3) PLGA microparticle production: 3:40 - 9:59
3.1) API encapsulated in PLGA microparticles: 3:40 - 5:07
3.2) PLGA microparticle production: 5:07 - 7:57
3.3) PLGA solvent extraction process: 7:57 - 9:59
4) PLGA core-shell microparticle production: 9:59 - 18:52
4.1) PLGA core-shell microparticle production method: 9:59 - 12:07
4.2) Multiple emulsions setup: 12:07 - 13:19
4.3) Results using 3D 100um flow focusing chip: 13:19 - 15:20
4.4) Single channel system & scale up with Telos: 15:20 - 17:38
4.5) Other particles: 17:38 - 18:52
5) Summary: 18:52 - 20:22
6) System explanation: 20:22 - 27:25
7) Software explanation: 27:25 - 31:35
9) Goodbyes & additional information: 31:35 - 31:59

To find out more please do not hesitate to contact us at: [email protected]
Or visit our website: dolomite-microfluidics.com