A primer to for some context on this historic moment in neuroscience.
History of the neuron doctrine, the synapse, and modern day connectomics.
Related press:
https://www.nature.com/articles/d4158...
See more connectomics data:
codex.flywire.ai
www.microns-explorer.org
Narration by Erica Brookhyser
ericabrookhyser.com
Music:
Chris Zabriskie - CGI Snake
References:
Vintage Microscope by Evan McNaught
https://skfb.ly/ouFMY
The histological slides and drawings of Cajal
Pablo Garcia-Lopez, Virginia Garcia-Marin, Miguel Freire
Frontiers in Neuroanatomy (2010)
Some Features of the Submicroscopic Morphology of Synapses in Frog and Earthworm
Eduardo D.P. De Robertis, Stanley Bennett
Biophysical and Biochemical Cytology (1955)
Organizing principles of astrocytic nanoarchitecture in the mouse cerebral cortex
Salmon CK, Syed TA, Kacerovsky JB, Alivodej N, Schober AL,
Sloan TFW, Pratte MT, Rosen MP, Green M,
Chirgwin-Dasgupta A, Mehta S, Jilani A, Wang Y,
Vali H, Mandato CA, Siddiqi K, Murai KK.
Current Biology, 2023 Mar 13;33(5):957-972.e5.
Drosophila model via Google DeepMind:
https://github.com/google-deepmind/dm...
dm_control: Software and tasks for continuous control
Saran Tunyasuvunakool, Alistair Muldal, Yotam Doron,
Siqi Liu, Steven Bohez, Josh Merel, Tom Erez,
Timothy Lillicrap, Nicolas Heess, Yuval Tassa
Software Impacts 2020
Neuronal wiring diagram of an adult brain
Sven Dorkenwald, Arie Matsliah, Amy R Sterling, Philipp Schlegel, Szi-chieh Yu, Claire E. McKellar, Albert Lin, Marta Costa, Katharina Eichler, Yijie Yin, Will Silversmith, Casey Schneider-Mizell, Chris S. Jordan, Derrick Brittain, Akhilesh Halageri, Kai Kuehner, Oluwaseun Ogedengbe, Ryan Morey, Jay Gager, Krzysztof Kruk, Eric Perlman, Runzhe Yang, David Deutsch, Doug Bland, Marissa Sorek, Ran Lu, Thomas Macrina, Kisuk Lee, J. Alexander Bae, Shang Mu, Barak Nehoran, Eric Mitchell, Sergiy Popovych, Jingpeng Wu, Zhen Jia, Manuel Castro, Nico Kemnitz, Dodam Ih, Alexander Shakeel Bates, Nils Eckstein, Jan Funke, Forrest Collman, Davi D. Bock, Gregory S.X.E. Jefferis, H. Sebastian Seung, Mala Murthy, the FlyWire Consortium
Nature 2024
Whole-brain annotation and multi-connectome cell typing quantifies circuit stereotypy in Drosophila
Philipp Schlegel, Yijie Yin, Alexander S. Bates, Sven Dorkenwald, Katharina Eichler, Paul Brooks, Daniel S. Han, Marina Gkantia, Marcia dos Santos, Eva J. Munnelly, Griffin Badalamente, Laia Serratosa Capdevila, Varun A. Sane, Markus W. Pleijzier, Imaan F.M. Tamimi, Christopher R. Dunne, Irene Salgarella, Alexandre Javier, Siqi Fang, Eric Perlman, Tom Kazimiers, Sridhar R. Jagannathan, Arie Matsliah, Amy R. Sterling, Szi-chieh Yu, Claire E. McKellar, FlyWire Consortium, Marta Costa, H. Sebastian Seung, Mala Murthy, Volker Hartenstein, Davi D. Bock, Gregory S.X.E. Jefferis
Nature 2024
A Complete Electron Microscopy Volume of the Brain of Adult Drosophila melanogaster
Zhihao Zheng, J. Scott Lauritzen, Eric Perlman, Camenzind G. Robinson, Matthew Nichols, Daniel Milkie, Omar Torrens, John Price, Corey B. Fisher, Nadiya Sharifi, Steven A. Calle-Schuler, Lucia Kmecova, Iqbal J. Ali, Bill Karsh, Eric T. Trautman, John A. Bogovic, Philipp Hanslovsky, Gregory S.X.E. Jefferis, Michael Kazhdan, Khaled Khairy, Stephan Saalfeld, Richard D. Fetter, Davi D. Bock
Cell 2018
Neuronal “parts list” and wiring diagram for a visual system
Arie Matsliah, Szi-chieh Yu, Krzysztof Kruk, Doug Bland, Austin Burke,
Jay Gager, James Hebditch, Ben Silverman, Kyle Willie, Ryan W. Willie,
Marissa Sorek, Amy R. Sterling, Emil Kind, Dustin Garner, Gizem Sancer,
Mathias F. Wernet, Sung Soo Kim, Mala Murthy, H. Sebastian Seung,
FlyWire Consortium
Nature 2024
Network Statistics of the Whole-Brain Connectome of Drosophila
Albert Lin, Runzhe Yang, Sven Dorkenwald, Arie Matsliah, Amy R. Sterling,
Philipp Schlegel, Szi-chieh Yu, Claire E. McKellar, Marta Costa,
Katharina Eichler, Alexander Shakeel Bates, Nils Eckstein, Jan Funke,
Gregory S.X.E. Jefferis, Mala Murthy
Nature 2024
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