Detailed MHC Class I Pathway Explained: Cytosolic Antigen Presentation to CD8+ T Cells

Discover the essential steps in the MHC Class I antigen presentation pathway that enable cytosolic proteins to be presented to CD8+ cytotoxic T lymphocytes. This video breaks down each phase of the process, from protein production in the cytosol to the surface expression of the MHC class I-peptide complex. Follow along with our timestamps for a clearer understanding:

0:00 – Protein production in the cytosol

1:00 – Proteolytic degradation of proteins

2:02 – Peptide transport from cytosol to ER

3:20 – Assembly of peptide-MHC class I complex in the ER

4:00 – Surface expression of peptide-MHC class I complex


Whether you’re studying for an exam or seeking to understand immune response mechanisms, this video provides a comprehensive guide to the MHC class I pathway, crucial for immune function. Like, share, and subscribe for more immunology breakdowns!