What is a FAST metabolism, Really?!

Paper: https://www.nature.com/articles/s4225...

BMJ human RCT: https://pubmed.ncbi.nlm.nih.gov/30429...

Video editing generously provided by Vincent at House of Macadamia
http://partner.houseofmacadamias.com/...
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0:00 - Fast vs Slow Metabolism, Intro
0:37 - Defining the Question
1:15 - New research in Nature Metabolism
2:26 - Fusion and Fission
2:44 - In obesity, Fission and Fusion are out of balance
3:03 - Results
5:35 - I'm Nerding out, Hard!
6:45 - Relevance
7:58 - LCD metabolic advantage

WHAT ABOUT specific dietary components and mitochondrial fusion? …

Thanks to @AnouarElHaji on X (Twitter) for reminding me about this fantastic 2018 Nat Comm paper and asking me to comment. I LOVE community input!
https://www.nature.com/articles/s4146...
(nb: I say remind because he points out “You used to have a YT video discussing this paper,” which I did, lol… TBT!)

Overview of this other mito fusion paper:

A set of experiments, including a double-blinded human RCT, showing that the saturated fat stearic acid (C18:0; this annotation means 18 carbon fatty acid with 0 double bonds) “[R]apidly and robustly causes mitochondrial fusion in people within 3 h after ingestion.”

The authors conclude: Stearic acid “C18:0 [i]s a dietary metabolite that is sensed by our bodies to control our mitochondria… [consistent with data that C18:0 may] decreas[e] cardiovascular and cancer risk.”

Rich sources of stearic acid include Tallow (~20g/100g) and Cocoa butter (34g/100g).

For more details, see THIS X post: https://x.com/nicknorwitz/status/1774...