Goldman Equation And The Resting Membrane Potential Explained | Clip

Welcome to Science With Tal!

In this clip of the Signal Propagation in the Neuron video, we will discuss how we can mathematically obtain the resting membrane potential of the neuron by using the Goldman equation. You will see here and in the comment section the time stamps associated with each topic that I’ve covered.

The video makes a lot of references to the Nernst equation and the equilibrium potential so make sure you watch that video to fully understand the concepts here.

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Timestamps

0:00 Introduction
0:22 Ion transporters role in creating ionic gradients
1:15 Sodium & potassium gradient (Na/K pump)
2:00 Calcium & chloride gradient (anti/symporters)
3:17 Recap & intuition on resting membrane potential
4:08 Intuition on ionic permeabilities
6:18 Goldman equation
8:40 A word on the driving force
9:13 What governs the resting membrane potential
9:34 Conclusion

Resources used

Here is a list of the resources that I’ve used to produce this video. (Author: title resource)

Dale Purves: Neuroscience (6th edition)
Eric Kandel: Principles of neural science (6th edition)
Alan Hodgkin & Andrew Huxley: A quantitative description of membrane current and its application to conduction and excitation in nerve
Alan Hodgkin & William Albert Hugh Rushton: The electrical constants of a crustacean nerve fibre.

To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided.

Video credits

Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo - jay (   • lukrembo - jay (royalty free vlog music)  )