Isotope Day 2022-NMR with Qiuwei Xu, PhD

"Examples of Quantitative NMR Analyses in Pharmaceutical Industry"

Dr. Qiuwei Xu, Senior Principal Scientist at Merck, discusses the application of quantitative NMR in the pharmaceutical industry. He highlights the unique properties of NMR (quantitative nature, repeatability) that make it an invaluable tool for solving various issues in drug development and manufacturing.

Key topics include:
-Structure confirmation and identification of chemical components
-Establishment of an 800-metabolite NMR reference library for metabolomics research
-Use of linear deconvolution methods to analyze overlapping signals in complex spectra
-Applications in metabolomics to investigate drug toxicity and biochemical pathways
-Role of NMR in vaccine process control and release
Characterization of polysaccharides using diffusion NMR

Dr. Xu emphasizes the importance of spectral quality, reproducibility, and advanced software tools for metabolite identification and quantification. He also acknowledges the long-standing interaction with Cambridge Isotope Laboratories (CIL) for NMR solvents and small molecule labeling.

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