Hacking the 3 Pathways of Aging

Harvard biologist and researcher David Sinclair has made some incredible claims about longevity with a focus on pills but is there more to lifestyle and diet that we can hack than he usually discusses? This video has 36 studies cited.
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Rich Roll Interview:    • A Harvard Geneticist Is Extending Hum...  

BROAD Study:
https://www.nature.com/articles/nutd2...

AMPK Study with Figure 2:
https://www.nature.com/articles/emm20...

AMPK Nexus of Aging Paper: 
https://www.ncbi.nlm.nih.gov/pmc/arti...

AMPK Metabolism Paper (Mitochondria):
https://www.sciencedaily.com/releases...

AMPK Aging Sensor Paper (Restriction Activates):
https://www.ncbi.nlm.nih.gov/pmc/arti...

Excess Calories and AMPK:
https://www.nature.com/articles/emm20...

Metformin and AMPK:
https://www.frontiersin.org/articles/...

Met Lowers Diabetes Mortality (50%):
https://care.diabetesjournals.org/con...

Met Lowers Diabetes Mortality (28%):
https://pubmed.ncbi.nlm.nih.gov/28802...

Met Extends Diabetic's Life 15% Longer Than Control:
https://dom-pubs.onlinelibrary.wiley....

AMPK and Exercise Main:
https://pubmed.ncbi.nlm.nih.gov/19196...

AMPK and HIIT:
https://pubmed.ncbi.nlm.nih.gov/19112...

AMPK Disappointing Fasting Result in Obese People:
https://journals.physiology.org/doi/f...

Muscle Mass and Longevity:
https://www.ncbi.nlm.nih.gov/pmc/arti...

Okinawan Paper:
https://pubmed.ncbi.nlm.nih.gov/17986...

Autophagy Paper:
https://www.frontiersin.org/articles/...

mTOR Paper Main:
https://www.frontiersin.org/articles/...

IGF-1 Vegans: https://pubmed.ncbi.nlm.nih.gov/12433...

Dairy and IGF-1:
https://pubmed.ncbi.nlm.nih.gov/20046...

Rapamycin Increased Mouse Longevity:
https://www.ncbi.nlm.nih.gov/pmc/arti...

Curcumin Golden TORGET: 
https://www.ncbi.nlm.nih.gov/pmc/arti...

Source of Dietary mTOR Inhibitors:
https://www.ncbi.nlm.nih.gov/pmc/arti...

ECGC Tea:
https://www.ncbi.nlm.nih.gov/pmc/arti...

Sirtuin Paper:
https://www.ahajournals.org/doi/10.11...

Sirtuin Anor-xia:
https://www.frontiersin.org/articles/...

Anor-xia Mortality:
https://jamanetwork.com/journals/jama...

Resveratrol Lowers IGF-1: https://pubmed.ncbi.nlm.nih.gov/20935...

Neurovascular coupling/brain blood flow in diabetics: 
https://www.ncbi.nlm.nih.gov/pmc/arti...

Increases T Killer Cells, decrease in inflammatory cytokines: https://pubmed.ncbi.nlm.nih.gov/28546...

NAD and Sirtuins Takes 2 to Tango:
https://www.nature.com/articles/npjam...

NMN Mouse Study:
https://www.sciencedirect.com/science...

NMN is the fountain of youth...if you are a mouse:
https://khn.org/news/a-fountain-of-yo...

NR Raised NAD:
https://academic.oup.com/ajcn/article...

NMN Safe in 10 People:
https://www.jstage.jst.go.jp/article/...

Foods with NMN:
https://www.sciencedaily.com/releases...

Antioxidant Diet = 38% lower all-cause mortality: 
https://link.springer.com/article/10....

Pilots DNA Damage and Antioxidants from Diet: https://pubmed.ncbi.nlm.nih.gov/19793...

Intro/Outro Song: Sedução Momentânea by Roulet:
http://freemusicarchive.org/music/Rou...

#DavidSinclair #Aging #Longevity