cGas Like Enzymes in Bacterial Immunity

Presented By: Aaron Whiteley, PhD



Speaker Biography: Dr. Whiteley is an Assistant Professor in the Department of Biochemistry at the University of Colorado Boulder. He earned his Ph.D. in Infectious Diseases and Immunity from the University of California, Berkeley in Dr. Daniel Portnoy’s lab. He then completed his postdoctoral training in Microbiology at Harvard Medical School in the laboratories of Dr. John Mekalanos and Dr. Philip Kranzusch. For full details on the Whiteley lab’s latest work, visit https://www.colorado.edu/lab/aaron-wh...



Webinar: cGas-Like Enzymes in Bacterial Immunity



Webinar Abstract: In all organisms, innate immune pathways sense infection and rapidly activate potent immune responses while maintaining a high degree of specificity to prevent inappropriate activation (autoimmunity). In humans, the innate immune receptor cGAS detects viral infection to produce the nucleotide second messenger cGAMP, which initiates STING-dependent antiviral signaling. Bacteria encode predecessors of the cGAS-STING pathway and bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases) detect bacteriophage infection to produce cGAMP.



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