Amphotericin B - Mechanism, side effects, precautions and uses

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Amphotericin B is a macrocyclic polyene antifungal antibiotic that can be used in various fungal infections including mucormycosis. This drug is given mainly by intravenous route and shows broad spectrum of activity. It mainly acts by binding to ergosterol in the fungal cell wall thereby disrupts membrane rigidity and increases leakiness. It acts as ionophore such that it forms an ion channel on the fungal membrane.

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