CPIC guideline for amitriptyline and CYP2C19, CYP2D6

This is a summary of the CPIC dosing guideline for tricyclic antidepressants and variation in the genes CYP2C19 and CYP2D6.

This video will focus on the recommendations for amitriptyline. Videos covering the recommendations for other tricyclic antidepressants can be found on the PharmGKB YouTube channel.

Guideline and supplemental information - https://cpicpgx.org/guidelines/guidel...

Annotated guideline and genotype picker - https://www.pharmgkb.org/guidelineAnn...

PharmGKB amitriptyline and nortriptyline pathway - https://www.pharmgkb.org/pathway/PA16...

CYP2C19 Gene Information Tables - https://www.pharmgkb.org/page/cyp2c19...

CYP2D6 Gene Information Tables - https://www.pharmgkb.org/page/cyp2d6R...

PharmVar - https://www.pharmvar.org/