LDL Risks and Benefits of Ketogenic Therapy- with Dr. William Cromwell

Dr. William Cromwell is an expert on heart health as a Lipidologist and the Chief Medical Officer of Precision Health Reports. In this interview with Dr. Bret Scher, he discusses the Lipid Energy Model (LEM) and whether or not lean mass hyper-responders (LMHR) on a ketogenic diet should be concerned about elevated LDL cholesterol. He argues for highly personalized medicine that modifies treatments based on individual needs. For example, in LMHRs, high LDL indicates an adaptive physiological response resulting from trafficking energy differently and this probably shouldn’t be treated the same as a traditional high LDL case.

Dr. Cromwell shares other tests, better than LDL, to get a clearer overall picture of heart health and make informed decisions about the need for any dietary modifications. As many LMHRs follow a ketogenic diet to treat other health conditions, they need to weigh the risks and benefits carefully.

Dr. Cromwell is proudly data-driven and sees evolutions in his perspective over time as a positive sign. He shares that more research and data are needed on the Lipid Energy Model and LMHRs.

Dr. Cromwell is a co-author on Dr. Nick Norwitz’s Oreo Study:

Oreo Cookie Treatment Lowers LDL Cholesterol More Than High-Intensity Statin Therapy in a Lean Mass Hyper-Responder on a Ketogenic Diet: A Curious Crossover Experiment
https://mdpi.com/2218-1989/14/1/73

Video on the Oreo Study:
   • Harvard Med Student & Scientist Lower...  

Video on the Lean Energy Model:
   • New Study Questions LDL Risk - An int...  

Dr. William Cromwell
precisionhealthreports.com
Twitter/X:
@Lipoprotein
@PreciseHlthRpt

Other studies mentioned:
Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a “Lean Mass Hyper-Responder” Phenotype
https://www.ncbi.nlm.nih.gov/pmc/arti...

Timestamps:
0:00 Introduction
1:54 The use of guidelines in cardiovascular care
5:57 Is all high LDL bad?
11:44 Why is individualized medicine difficult to find?
14:12 Which cardiac tests can you ask your doctor for?
20:25 Dr. Cromwell on the lipid energy model
27:29 High LDL as a possible adaptive process from the body
29:00 Dr. Cromwell on Nick Norwitz's Oreo study
33:58 How to apply context to medical care
39:50 Letting data teach and inform medicine
44:04 Conclusion

About us:
Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.

Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.


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