Synthetic Genomics or "Genome Writing"

Renowned geneticist Jef Boeke, Ph.D., Institute for Systems Genetics, NYU Langone Health, discusses groundbreaking advancements in genetic engineering and synthetic biology, highlighting the innovative "Assemblatron," and the ambitious "Dark Matter Project."

Boeke begins by explaining the concept of synthetic genomes and "Big DNA" and showcasing how scientists can design and construct DNA from scratch to create entirely new organisms or modify existing ones.

Boeke introduces the "Assemblatron," a cutting-edge platform designed to automate the assembly of large DNA constructs. He discusses how this technology can accelerate research and development in synthetic biology, making it possible to create complex genetic systems more efficiently and accurately.

The presentation then transitions to the "Dark Matter Project," an initiative aimed at uncovering the unknown functions of vast regions of non-coding DNA, often referred to as the "dark matter" of the genome. Boeke shares insights into how this project could revolutionize our understanding of genetics and lead to novel discoveries and gene therapies. Boeke describes the development of an animal model for X-Linked dystonia-parkinsonism (XDP) and how a synthetic genomics approach to investigate the XDP/TAF1 locus has potential to lead to the development of gene therapies.

Whether you're a scientist, student, or simply curious about the future of genetics, this presentation offers a captivating glimpse into the possibilities of synthetic genomes and the innovative projects driving the field forward.

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*Institute for Systems Genetics*: https://med.nyu.edu/departments-insti...
*The Dark Matter Project*: https://www.thedarkmatterproject.org/

This presentation was part of the Genome Technology Forum, a hybrid event held at The Jackson Laboratory in collaboration with the National Human Genome Research Institute.

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