Hodgkin-Huxley Model of Voltage-Gated Channels Explained (Gating Variables n, m, h) | Clip

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In this clip of the Signal Propagation in the Neuron video, we will discuss the Hodgkin-Huxley model of voltage gated channels (sodium and potassium). The video will focus on understanding the respective gating variables (n, m, h) for sodium and potassium voltage gated channels. To understand them, we will explore differential equations that describe the time and voltage dependence of these variables. The video will also cover the molecular structures of the channels to understand the voltage dependence and how ions pass through.

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Timestamps

0:00 Introduction
0:17 Motivation (patch clamp of voltage gated channels)
1:26 Molecular structure of VGC
2:42 Molecular mechanism of VG potassium channels
4:18 Probabilistic model of VG potassium channels
6:10 Time dependence of gating variable (n)
9:33 Voltage dependence of gating variable (n)
10:38 Voltage and time analysis of VG potassium channels
12:25 Molecular mechanism of VG sodium channels
13:22 Probabilistic model of VG sodium channels
15:18 Time and voltage analysis gating variable (m)
16:12 Time and voltage analysis gating variable (h)
16:55 Analysis of VG potassium and sodium channels together
20:41 Conclusion

Resources used

Here is a list of the resources that I’ve used to produce this video. (Author: title resource)

Dale Purves: Neuroscience (6th edition)
Eric Kandel: Principles of neural science (6th edition)
Alan Hodgkin & Andrew Huxley: A quantitative description of membrane current and its application to conduction and excitation in nerve
Alan Hodgkin & William Albert Hugh Rushton: The electrical constants of a crustacean nerve fibre.

To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided.

Video credits

Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo - jay (   • lukrembo - jay (royalty free vlog music)  )