NMN Unveiled: The Science Fueling the Future of Longevity

Learn all about Nicotinamide Mononucleotide, commonly known as NMN, as a potentially huge advancement in aging research

Christopher Voss, MD, MS, FCCP
Board-certified in Lifestyle Medicine and Obesity Medicine

Cited papers:

1. Yagi M, Do Y, Hirai H, Miki K, Toshima T, Fukahori Y, et al. Improving lysosomal ferroptosis with NMN administration protects against heart failure. Life Sci Alliance. 2023;6. doi:10.26508/lsa.202302116.

2. Zhang R, Chen S, Wang Z, Ye L, Jiang Y, Li M, et al. Assessing the effects of nicotinamide mononucleotide supplementation on pulmonary inflammation in male mice subchronically exposed to ambient particulate matter. Environ Health Perspect. 2023;131. doi:10.1289/EHP12259.

3. Popescu R, Dinischiotu A, Soare T, Vlase E, Marinescu GC. NMN works in HFD-induced T2DM by interesting effects in adipose tissue, and not by mitochondrial biogenesis. bioRxiv. 2023. doi:10.1101/2023.10.27.564318.

4. Igarashi M, Yamauchi T. Insight into the application of nicotinamide mononucleotide (NMN) to age-related disorders. J Cell Mol Immunol. 2023. doi:10.46439/immunol.2.014.

5. Zhang D, Yau LF, Bai L, Tong T, Cao KY, Yan TM, et al. Hydroxyapatite-based nano-drug delivery system for nicotinamide mononucleotide (NMN): significantly enhancing NMN bioavailability and replenishing in vivo nicotinamide adenine dinucleotide (NAD+) levels. J Pharm Pharmacol. 2023. doi:10.1093/jpp/rgad090.

6. Irie J, Inagaki E, Fujita M, Nakaya H, Mitsuishi M, Yamaguchi S, et al. Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men. Endocr J. 2020. doi:10.1507/endocrj.EJ19-0313.

7. Igarashi M, Nakagawa-Nagahama Y, Miura M, Kashiwabara K, Yaku K, Sawada M, et al. Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. NPJ Aging. 2021. doi:10.21203/RS.3.RS-455083/V1.

8. Liao B, Zhao Y, Wang D, Zhang X, Hao X, Hu M. Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study. J Int Soc Sports Nutr. 2021;18. doi:10.1186/s12970-021-00442-4.

9. Cros CD, Cannelle H, Laganier L, Grozio A, Canault M. Safety evaluation after acute and sub-chronic oral administration of high purity Nicotinamide mononucleotide (NMN-C®) in Sprague-Dawley rats. Food Chem Toxicol. 2021;112060. doi:10.1016/j.fct.2021.112060.