Blood Lipids and Cardiovascular Risk: Everything You Need to Know

This video covers the role of blood lipids, specifically LDL-cholesterol, in atherosclerosis and cardiovascular disease.

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- VIDEO DESCRIPTION -
In this video, we are discussing in detail the basics of atherosclerosis, lipid, and lipoprotein metabolism, the impact of LDL-cholesterol and other blood lipids on atherosclerotic cardiovascular disease (ASCVD), and which specific blood tests to get and how to interpret them. We are also addressing six common claims that argue that blood lipids and LDL-cholesterol do not affect ASCVD, or that their impact is negligible and that other risk factors are far more important.

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- TIMESTAMPS -
00:00 Introduction
02:32 The Basics of Atherosclerotic Cardiovascular Disease
04:30 Basics of Blood Lipids and Lipoproteins
08:58 Do LDL Particles Cause ASCVD?
13:17 Is LDL-Cholesterol the Best Blood Lipid Measure to Assess ASCVD Risk?
22:14 Addressing Common Claims Suggesting that LDL-Cholesterol is not a Risk Factor for ASCVD
23:37 Claim #1: Many People Who Have Heart Attacks Have Normal LDL-Cholesterol
24:08 Claim #2: Lowering LDL-Cholesterol Reduces the Absolute ASCVD Risk Only Minimally
28:58 Claim #3: Only Small, Dense LDL Particles are Atherogenic
36:04 Claim #4: Other Risk Factors Are More Important Than LDL-Cholesterol
39:25 Claim #5: Elevated LDL-Cholesterol on Low-Carbohydrate or Ketogenic Diets is Not Atherogenic
54:03 Claim #6: Cholesterol Cannot Be Harmful Because It’s a Natural Substance Made by the Body and Needed for Numerous Important Functions
55:40 Summary & Conclusions

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An excellent academic talk about the cumulative LDL-cholesterol exposure hypothesis of ASCVD:
   • LDL-C Cumulative exposure hypothesis ...  
YouTube video of a presentation by Dave Feldman at Low Carb Denver 2023 about the Lean Mass Hyperresponder phenotype::
   • Dave Feldman presentation: ApoB, Chol...  
Presentation of baseline data from the LMHR study by Dr. Matthew Budoff:
   • BREAKING – New Analysis of Heart Scan...  
Discussion of the baseline data from the LMHR study with Dave Feldman and Nick Norwitz:
https://www.youtube.com/live/rL9uabr-...
Mayo-Clinic Heart Disease Risk Calculator:
https://www.mayoclinichealthsystem.or...

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