Best Supplement/Nootropic For Memory? (Uridine Monophosphate)

Best Supplement/Nootropic For Memory? (Uridine Monophosphate)

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The ability of the brain to make more phosphatidylcholine (PC), and related membrane constituents when presented with additional uridine, DHA, and choline, requires that the enzymes which catalyze the steps in PC synthesis have a special biochemical property: Each enzyme must exhibit unusually poor affinity for its substrate, so that, at the uridine, DHA, and choline concentrations normally present in brain cells, many enzyme molecules will not be attached to their substrate and, thus, will not be able to act on it. However, when additional substrate is provided—by administering the nutrients to raise their blood levels—more enzyme molecules become engaged, and more of their product is formed [2]. We had first observed a similar “precursor-dependence” many years earlier involving the conversion of a different nutrient, the amino acid tryptophan, to serotonin, a neurotransmitter [8]: Giving animals tryptophan rapidly increased the formation and release of brain serotonin. Similar precursor-dependence was subsequently shown to characterize numerous other neurotransmitters [9].

The concentrations of uridine, DHA, and choline required for engaging just half of the molecules of each enzyme needed for converting choline to PC (i.e., each enzyme’s Michaelis-Menten constant [Km]) were found to be very high in relation to their actual brain concentrations. Hence, administering each of the nutrients does in fact increase the production, and, ultimately, the levels of brain PC [1]. Moreover, the effect of giving uridine, DHA, and choline together is additive or greater. An additional biochemical mechanism activated by the uridine in SOUVENAID® enables the brain also to increase production of the special proteins found in synaptic membranes. It involves the activation of P2Y receptors, a particular family of brain receptors that can affect neuronal differentiation and synaptic protein synthesis [10]. P2Y receptor activation is also involved in the processes that shape the newly-formed membrane into neurites, dendritic spines, and synapse [10].


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