LC Troubleshooting—Retention Time Shift

What can cause my retention times to change when I am doing liquid chromatography? There are lots of potential causes and temperature fluctuations, leaks, and particulate contamination are a few of them. If we want to maintain stable, reproducible retention times, there are a few things that we should monitor and maintain, and when we do that, they should be rock solid.

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Additional Resources

LC Column Cleaning Recommendations | https://www.restek.com/articles/reste...

Shifting Analyte Retention Times or Matrix Interferences? | https://www.restek.com/chromablograph...

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Restek Recommended Tools & Parts

LC Columns | https://www.restek.com/c/1119

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