IL-1R1 Contributes to Stress-Induced Social Interaction Deficits - Ning Quan PhD, Synchrony 2023

Early life stress (ELS) is one of the common environmental factors that changes neurodevelopmental trajectory. ELS is strongly associated with neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. Increased cytokine production is one of the common responses to ELS.

The proinflammatory cytokine interleukin-1 (IL-1) acting through its receptor interleukin-1 receptor-1 (IL-1R1) has critical roles in non-inflammatory neuroimmune activities (such as in maintaining the homeostasis of the central nervous system and regulating neural circuit functions) and neuroinflammation. Furthermore, recent research has shown that neuronal IL- 1R1 is also important for cognition and social interaction in adult mice.

In this talk Dr Quan presents findings by his group on the role of IL-1R1 in neurodevelopment and related cognitive and affective functions. The researchers assessed ELS- induced social interaction changes and found that nIL-1R1 is necessary for mediating maternal separation-induced deficits in social interaction and social recognition later in life. These findings suggest that: 1) nIL-1R1 is tightly regulated during brain development correlating with its critical role in the control of neuronal maturation by and 2) nIL-1R1 modulates the ELS-induced stress responses in DG which leads to long-lasting social interaction abnormalities by changing neuronal activity and/or plasticity in the DG.

🎥 This talk was part of Synchrony 2023 Online Symposium - 'From Bench to Biopharma', organised by the The BRAIN Foundation

🎥 Synchrony 2023 playlist:    • Synchrony Symposium 2023  

Synchrony https://brainfoundation.org/synchrony... is the first and only international symposium on translational research in #autism, that brings together academia, #biotech, #pharmaceuticalcompanies and venture partners from around the world with the mission to improve health and quality of life of people with #autismspectrumdisorder.


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The BRAIN Foundation https://brainfoundation.org/ is a 501c(3) non-profit. The founders of BRAIN envision a world where every child and adult on the autism spectrum is healthy, participates fully in education and employment, and has a better quality of life. It aims to catalyze research that results in evidence-based interventions for the disabilities associated with autism, and also results in better medical standard of care. To accomplish this, it funds impactful research through #philanthropy and our network of partners in the venture, corporate, and grassroots community.