Synthetic Peptide Libraries Part 4: Edward J. Will

Case studies: Picomole-scale synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification, Edward J. Will

Purification-free synthesis and screening of thousands of cyclic peptides
The lab of Prof. Christian Heinis at EPFL (Lausanne, Switzerland) is on the cutting-edge of technology by applying robotic automation, acoustic dispensing and tip-less liquid handlers for performing chemical synthesis in microtiter format. In this webinar, experienced members of his lab will describe their latest work in high-throughput chemistry of peptidic macrocycle libraries for screening against challenging targets.

Three-part lecture:
Talk 1: Dr. Alexander L. Nielsen (2nd year postdoctoral researcher)
Introduction to peptidic macrocycles and synthetic approaches for their preparation in high-throughput

Talk 2: Mischa Schüttel (4th year PhD student)
Solid-phase peptide synthesis in 4×384-well plates

Talk 3: Edward J. Will (3rd year PhD student)
Case studies: Picomole-scale synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification