Synthetic Peptide Libraries Part 3: Mischa Schüttel

Solid-phase peptide synthesis in 4×384-well plates, Mischa Schüttel

Purification-free synthesis and screening of thousands of cyclic peptides
The lab of Prof. Christian Heinis at EPFL (Lausanne, Switzerland) is on the cutting-edge of technology by applying robotic automation, acoustic dispensing and tip-less liquid handlers for performing chemical synthesis in microtiter format. In this webinar, experienced members of his lab will describe their latest work in high-throughput chemistry of peptidic macrocycle libraries for screening against challenging targets.

Three-part lecture:
Talk 1: Dr. Alexander L. Nielsen (2nd year postdoctoral researcher)
Introduction to peptidic macrocycles and synthetic approaches for their preparation in high-throughput

Talk 2: Mischa Schüttel (4th year PhD student)
Solid-phase peptide synthesis in 4×384-well plates

Talk 3: Edward J. Will (3rd year PhD student)
Case studies: Picomole-scale synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification


https://www.epfl.ch/labs/lppt/

Selected publications:
•     Nat.Commun. 13, 3823 (2022).
https://www.nature.com/articles/s4146...
•     Org. Biomol. Chem. 20, 5699–5703 (2022).
https://doi.org/10.1039/D2OB00910B
•     ACS Chem. Biol. 17, 181–186 (2022).
https://pubs.acs.org/doi/full/10.1021...
•     Angew. Chem. Int. Ed. 60, 21702–21707 (2021).
https://onlinelibrary.wiley.com/doi/1...
•     Chem. Sci. 11, 7858–7863 (2020).
https://doi.org/10.1039/D0SC01944E
•     Sci. Adv. 5, eaaw2851 (2019).
https://www.science.org/doi/full/10.1...