How APOE4 Affects Brain Lipoproteins and Dementia Risk | The Proof Clips EP

In this clip, Dr. Thomas Dayspring and Kelly Niotis delve into the fascinating role of the APOE4 gene in brain health and its link to neurodegenerative diseases like Alzheimer's and Lewy Body dementia. While APOE is a key protein involved in cholesterol transport, different variations, such as APOE2, APOE3, and APOE4, influence the brain's cholesterol handling in distinct ways. Those with APOE4 face higher risks of Alzheimer’s, as this variant often leads to inefficiencies in delivering cholesterol to neurons, causing toxic buildup and potential cell damage.

The discussion explores how brain-specific lipoproteins work independently of those in the bloodstream, crossing the blood-brain barrier in unique ways to protect brain cells. Dr. Dayspring and Kelly Niotis also shed light on emerging therapies targeting APOE4’s dysfunction in cholesterol transport, including the potential for APOA1 to modify APOE4's impact on brain HDL.

Discover the complexities of APOE genetics, the brain’s lipid management system, and why understanding these mechanisms is essential for addressing Alzheimer’s risk and future therapeutic developments.

Stream the full episode on YouTube:    • Revolutionizing Brain Health: Genetic...  
Or listen on your favourite podcasting platform: https://theproof.com/cholesterol-and-...

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit https://theproof.com/friends/.

• The Proof with Simon Hill - https://theproof.com/podcast/
• Book: The Proof is in the Plants - https://theproof.com/book/
• Apple Podcast - https://podcasts.apple.com/gb/podcast...
• Spotify - https://open.spotify.com/show/7bAIJCV...
• Instagram -   / theproof  
• Twitter -   / theproof  
• Facebook -   / theproofwithsimonhill  
• Plant-Based Ferments Guide - https://theproof.com/ferments/
• Two-week meal plan - https://theproof.com/mealplan/
• Plant Performance - https://theproof.com/plant-performance/
• Use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends.