An essential PAT technology for downstream processing in AAV manufacturing

Amidst soaring demand for gene therapies using adeno-associated virus (AAV) vectors, robust and efficient analytical methods are pivotal for ensuring high AAV production quality.

Get to know mass photometry – a game-changer in AAV downstream processing. Quick, precise, and serotype-agnostic, it consistently measures empty-full and partially filled AAVs with minimal sample requirements.

In this webinar, discover the role mass photometry can play in characterizing AAV samples. Through a case study presented by ABL, a CDMO providing end-to-end viral vector manufacturing services, you will learn how mass photometry expedites early process development, helps optimize the polishing step, and rapidly determines critical quality attributes of AAV samples. You can also gain insights into the broader applications of mass photometry and learn about a tailored software solution for GMP-regulated environments.

TIMESTAMPS :

0:00 – Introduction (host)
0:17 – Introductions (Racha)
0:31 – The technology gap in AAV analytics (Racha)
1:45 – How does mass photometry work? (Racha)
3:59 – Mass photometry instruments for AAV analysis (Racha)
5:15 – Introduction by Quentin Bazot
5:43 – The main challenge in AAV manufacturing (Quentin)
7:18 – Overview of Quentin’s talk
7:44 – Measuring AAV standards with the SamuxMP (Quentin)
9:15 – Estimating AAV titer with the SamuxMP (Quentin)
10:51 – Characterizing AAVs at early stages (Quentin)
15: 35 – Assessing transgene size with mass photometry (Quentin)
17:16 – Optimizing the polishing step with mass photometry (Quentin)
21:56 – Conclusions to Quentin’s talk
22:44 – Comparing the Samux with other techniques (Racha)
23:41 – Refeyn’s mass photometry offer for GMP (Racha)

ABOUT REFEYN'S CHANNEL
Refeyn pioneers analytical instruments that put molecular mass measurement capabilities within easy reach for scientists. Refeyn instruments feature mass photometry technology, which uses light to quantify the mass of single particles in solution without labels. Find our latest video resources on YouTube, including webinars, tutorials, and much more!

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FURTHER RESOURCES:
SamuxMP product page - https://www.refeyn.com/samuxmp-mass-p...
SamuxMP Auto product page - https://www.refeyn.com/samuxmp-auto-m...
Blog - Everything you need to know about analyzing AAVs with mass photometry - https://www.refeyn.com/post/analysing...
Webinar - Are your AAVs filled? Determine rapidly with mass photometry -    • [Webinar] Are Your AAVs Filled? Deter...  
Webinar - Harnessing mass photometry for AAV sample characterization in GMP-regulated environments -    • Harnessing mass photometry for AAV sa...  

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