MOGAD (Myelin Oligodendrocyte Glycoprotein Associated Disease) Explained by Neurologist

0:32 Symptoms/MRI
5:55 Pathophysiology
6:41 Anti-MOG-IgG
8:11 Epidemiology
9:39 Diagnostic Criteria
11:14 Prognosis
13:27 Pregnancy
13:38 Treatment (acute attacks)
15:14 Treatment (attack prevention)
22:09 Clinical Trials

Selected Sources:

Delimiting MOGAD as a disease entity using translational imaging: https://pubmed.ncbi.nlm.nih.gov/38333...
Dr. Eoin Flanagan’s video on MOGAD:    • Myelin Oligodendrocyte Glycoprotein A...  
Effectiveness of immunotherapies in relapsing myelin oligodendrocyte glycoprotein antibody-associated disease: https://pubmed.ncbi.nlm.nih.gov/38314...
Neuroimaging features in inflammatory myelopathies: A review: https://www.frontiersin.org/journals/...
Pregnancy and post-partum in patients with myelin-oligodendrocyte glycoprotein antibody-associated disease: https://pubmed.ncbi.nlm.nih.gov/36453...
The MOG antibody non-P42 epitope is predictive of a relapsing course in MOG antibody-associated disease: https://pubmed.ncbi.nlm.nih.gov/38290...
Radiological Features for Outcomes of MOGAD in Children: A Cohort in Southwest China: https://www.dovepress.com/radiologica...

CNS Demyelinating Attacks Requiring Ventilatory Support With Myelin Oligodendrocyte Glycoprotein or Aquaporin-4 Antibodies: https://www.neurology.org/doi/10.1212...
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): Clinical features and diagnosis: https://www.uptodate.com/contents/mye...
Pathophysiology of myelin oligodendrocyte glycoprotein antibody disease: https://www.frontiersin.org/journals/...
Predictors of relapsing disease course following index event in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): https://www.sciencedirect.com/science...
Interleukin-6 Receptor Blockade in Treatment-Refractory MOG-IgG-Associated Disease and Neuromyelitis Optica Spectrum Disorders: https://pubmed.ncbi.nlm.nih.gov/34785...
Evaluation of treatment response in adults with relapsing MOG-Ab-associated disease: https://jneuroinflammation.biomedcent...


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Dr. Brandon Beaber is a board-certified neurologist with subspecialty training in multiple sclerosis and other immunological diseases of the nervous system. He is a partner in the Southern California Permanente Medical Group and practices in Downey, California (South Los Angeles). He has several publications on MS epidemiology and has participated in clinical trials for MS therapeutics. You can follow him on twitter @Brandon_Beaber where he regularly posts about MS news and research.

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he video material by Dr. Brandon Beaber is general educational material on health conditions and is not intended to be used by viewers to diagnose or treat any individual's medical condition. Specifically, this material is not a substitute for individualized diagnostic and treatment advice by a qualified medical/health practitioner, licensed in your jurisdiction, who has access to the relevant information available from diagnostic testing, medical interviews, and a physical examination. To the extent that Dr. Beaber endorses any lifestyle change, behavioral intervention, or supplements, the viewer should consult with a qualified healthcare professional to determine the safety and efficacy of the intervention in light of their individualized information.