Cellular Neurothekeoma vs Nerve Sheath Myxoma - Dermpath Lookalikes

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: https://kikoxp.com/posts/5084 (dermpath) & https://kikoxp.com/posts/5083 (bone/soft tissue sarcoma pathology).

Confused about "neurothekeoma"? You are not alone. And hopefully you'll feel better after watching this video, which discusses dermal nerve sheath myxoma (formerly called conventional or myxoid neurothekeoma) and cellular neurothekeoma. The two entities are totally unrelated, but because of some overlapping histologic features and a lot of very confusing nomenclature used in older literature, there has been enormous confusion about them that has vexed generations of pathologists. This video is dedicated to my friend and colleague, Dr. Jaime Arturo Mejia, who loves to discuss these entities and to lament the confusion they cause for everyone.

A list of my nerve sheath tumor videos:
Schwannoma: https://kikoxp.com/posts/4093
Malignant peripheral nerve sheath tumor (MPNST) - classic, epithelioid, & Triton: https://kikoxp.com/posts/4092
Nerve sheath myxoma vs cellular neurothekeoma: https://kikoxp.com/posts/4103
Neurofibroma, Neurofibromatosis-1, and Low Grade MPNST: https://kikoxp.com/posts/4091
Palisaded encapsulated neuroma: https://kikoxp.com/posts/3844

Dermal nerve sheath myxoma:
Finger/hand usually
Hypocellular, bland cytology, no/low mitoses
Recurrence common
S100 & SOX-10 (+)
True nerve sheath tumor

Cellular neurothekeoma:
Face/shoulder/arm (usually not finger/hand)
Cellular, but may have hypocellular myxoid areas
May have marked atypia & many mitoses = still benign
Recurrence uncommon
S100 & SOX-10 negative
NOT a nerve sheath tumor (name is misnomer)

Suggested reading:
https://www.ncbi.nlm.nih.gov/pubmed/1...
https://www.ncbi.nlm.nih.gov/pubmed/1...
https://www.ncbi.nlm.nih.gov/pubmed/1...
https://www.ncbi.nlm.nih.gov/pubmed/2...

Please check out my Soft Tissue Pathology & Dermatopathology survival guide textbooks: http://bit.ly/2Te2haB ‬

This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.

Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.

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